Accelerating Progress Against Gallbladder and Bile Duct Cancers

Join the AACR in supporting research to find better ways to prevent and treat gallbladder cancer and bile duct cancer.

Gallbladder cancer and bile duct cancer are relatively rare forms of cancer.

The gallbladder is a pear-shaped organ in the abdomen, below the liver. It collects and stores bile – a fluid made by the liver to aid with digestion of fats. The bile ducts are thin tube-like vessels that carry bile from the liver to the gallbladder and small intestine.

An estimated 12,190 people living in the United States were diagnosed with gallbladder cancer in 2018, according to data from the National Cancer Institute (NCI). Extrahepatic bile duct cancer is a rare disease in which cancer cells form in the ducts that are outside the liver. Cancer can also develop in the bile ducts inside the liver. Bile duct cancer is also called cholangiocarcinoma.

Symptoms of both gallbladder and bile duct cancer include yellowing of the skin and/or the whites of the eyes (jaundice), abdominal pain, and fever. In addition, gallbladder cancer symptoms include nausea and vomiting, bloating, and lumps in the abdomen.

February is Gallbladder and Bile Duct Cancer Awareness Month.

How Do Gallbladder Cancer and Bile Duct Cancer Develop?

Gallbladder cancer begins in the inner, or mucosal, layer of the organ, most commonly in cells that make and release mucus and other fluids. It then spreads into the muscle and outer layers. Bile duct cancer forms in cells in any portion of the bile duct network.

Risk factors for bile duct cancer include having chronic colitis, certain liver diseases, and infection with a worm parasite known as the clonorchis sinensis, or the Chinese liver fluke. Risk factors for gallbladder cancer are being a woman and being Native American.

Both forms of cancer are often diagnosed at later, more advanced stages because most people display few, if any, recognizable symptoms at early stages.

What is the AACR Doing in This Area?

The Warner Fund donated funds to the AACR to support early-career investigators who presented meritorious work relating to
cholangiocarcinoma at the AACR Annual Meeting 2018. The 2018 AACR-Warner Fund Scholar-in-Training Awards went to: Akiyoshi Kasuga, MD, of the Keio University School of Medicine in Tokyo; and Jisce R. Puik, of the VU University Medical in Amsterdam, for their work in the field of cholangiocarcinoma.

The 2018 AACR Scholar-in-Training Award in Honor of Cathy Whalen supports a young investigator presenting a high-quality abstract in bile duct cancer at the AACR Annual Meeting 2018. The award went to Sunyoung S. Lee, MD, PhD, of the Roswell Park Comprehensive Cancer Institute.

The AACR's mission is to prevent and cure all forms of cancer.​

Last year the AACR provided over $64 million in grants and awards funding lifesaving cancer research. There are many ways you can support our mission to prevent and cure all cancers. Take Action

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